2-5A-PNA COMPLEXES : A NOVEL CLASS OF ANTISENSE COMPOUNDS

Jeroen C. Verheijen,Suzanne F Bayly,Mark R. Player,Paul F. Torrence,G.A. van der Marel,J.H. van Boom

2-5A-PNA COMPLEXES : A NOVEL CLASS OF ANTISENSE COMPOUNDS

1999

Jeroen C. Verheijen
Suzanne F Bayly
Mark R. Player
Paul F. Torrence
G.A. van der Marel
J.H. van Boom

Abstract This paper presents the fully automated solid phase synthesis of 2-5A-PNA hybrids. These stable antisense probes cause RNase L mediated hydrolysis of target RNA sequences.

Keywords:

Sense (molecular biology)
RNA
Biochemistry
Hydrolysis
Solid-phase synthesis
RNase P
Molecular biology
Chemistry
Combinatorial chemistry
fully automated

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