GW28-e0445 Triptolide attenuates cardiac fibrosis via NLRP3 inflammasome-mediated MAPK/TGF-β1/Smad pathway

Myocardial fibrosis functions as an independent risk factor involved in various cardiac diseases such as hypertension, left ventricular diastolic dysfunction and myocardial infarction. Our previous study indicated triptolide (TP), a diterpenoid isolated from Tripterygium wilfordii , attenuated