Emulsions Containing 9,1O-Dimethyl-1, 2-Benzanthracene

Emulsionsoffatsuitableforintravenous administration havebeenusedinthislaboratoryas@ sourceofcalories,asanaidinthestudyoflipidmetabolism,andasavehicleforfat-solublematenials.ThelatterusehasbeenofvalueinstudieswithratsontheeffectsoftheintravenousinjectionCofcarcinogenichydrocarbons. Severalinvestigationshavebeenreportedinwhichemulsionsorsuspensionsofcarcinogeniccompoundshavebeengivenintravenously toexperimental animals.AndervontandLorenz(1)reportedthatmiceoftheC3HstraindevelopedpulmonarytumorsfollowingtheintravenousinjectionofsuspensionsofI,@,5,6-dibenzanthnacene. Shimkin (6)reportedthatstrainAmicedevelopedpulmonarytumorsafterintravenous injectionof@0-methylcholanthreneinanemulsion.NoneoplasmswerefoundbyGarayandBerencsi(3)todevelopinmiceorrabbitsaftertheintravenous administration ofsuspendedS,4-benzpyrene.Therapidexcretionofintravenously administered radioactivedibenzanthracenehasbeenreportedbyHeidelbergerand