STUDY OF THREE-COMPONENT REACTIONS BETWEEN 5-AMINO-3-METHYLISOXAZOLE, N -ARYLAMIDES OF ACETOACETIC ACID, AND AROMATIC ALDEHYDES

A three-component cyclocondensation between 5-amino-3-methylisoxazole, N‑arylamides of aceto-acetic acid, and aromatic aldehydes was studied under the conditions of thermal activation and ultrasonication. Upon heating in n -butanol, depending on the substituent in aldehyde, the reaction produced either N ,4‑diaryl-3,6-dimethylisoxazolо[5,4- b ]pyridine-5-carboxamides, or their 4,7‑dihydro derivatives. Ultrasonication unexpectedly produced N 1 , N 3 ,2-triaryl-4-hydroxy-4-methyl-6-oxocyclo-hexane-1,3-dicarboxamides. How to Cite Tkachenko, V. V.; Muravyova, E. A.; Shishkina, S. V.; Shishkin, O. V.; Desenko, S. M.; Chebanov, V. A. Chem. Heterocycl. Compd. 2014 , 50 , 1166. [ Khim. Geterotsikl. Soedin. 2014 , 1263.] For this article in the English edition see DOI 10.1007/s10593-014-1578-0