Hyperprolactinemia And Hypergonadotropins In Infertile Males With Sever Oligospermia And Azoospermia

Serum prolactin (PRL), luteinizing hormone (LH), and follicle stimulating hormone (FSH) were analyzed in 120 infertile male including: 78(65%) asthenozoospermic, 24(20%) sever oligospermic, 10(8.3%), oligospermic, and 8(6.7%) azoospermic using immunometric assay. Hormonal seric values were correlated with sperm count, motility, and antisperm antibody as detected by Latex Agglutination Test . No clinical importance of autoantibody was appeared in all groups of subjects investigated. A significant week correlation was found between serum LH and sperm count in all infertile males (p=0.002) but not motility, whereas PRL and FSH showed an inverse relationship with motility (r = -0.469 p<0.005, r = -0.316 p< 0.005) respectively. The mean PRL level (reference range 2.5-17 ng/ml) was found to be higher in sever oligospermia and azoospermia (mean 17.9 ±12.7 and 18.6 ±11.7 respectively). On the other hand, the mean LH levels (reference range 0.8-7.6 mIU/ml) and FSH (reference range 0.7-11.1 mIU/ml) was found to be higher in azoospermia (19.9±14.9 and 24.8±32.4 respectively). Increasing profile of FSH and PRL is useful in routine investigation of azoospermic male (p=0.001). These data demonstrate that when using lower semen parameters, the most common serum hormone abnormality is increased in PRL and gonadotrophins. The study gives an impression concerning serum PRL, FSH, and LH in infertile males in Jordan.