Direct Mannich Reaction Mediated by Fe(Cp)2PF6 under Solvent‐Free Conditions.
2010
Abstract Fe(Cp) 2 PF 6 (5 mol %) efficiently catalyzed Mannich reaction of aldehydes, anilines, and ketones under solvent-free condition to give β-amino-ketones in high yield (up to 94%) within 30 min with anti -isomer in excess. Simple experimental conditions and product isolation procedure makes this protocol potential for the development of clean and environment-friendly strategy for the synthesis of β-amino-ketones.
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