The Exposome: Pursuing the Totality of Exposure

Environmental determinants of health need to be measured and analyzed using system approaches that account for interactions between different agents that can elicit a biological response. The exposome offers a useful framework to examine the totality of exposures and their contribution to health and disease. Advances in exposure science, analytical chemistry, molecular biology, and toxicology have primed us to investigate the health effects of exposure to mixtures and concomitant exposures.