Опыт применения медикаментозной терапии при гипертрофической кардиомиопатии

Aim. To assess the impact of drug therapy on the clinical course of hypertrophic cardiomyopathy in long term. Methods. 90 patients with hypertrophic cardiomyopathy (males — 55, females — 35, mean age 42,0±1,52 years) were observed for a long period of time. Non-obstructive form of the disease was diagnosed in 72 (80%) patients, obstructive — in 18 (20%) patients. Average follow-up duration was 15,0±0,73 years. Drug therapy was received by 54 patients, 21 patients were treated with beta-blockers, 16 patients — with verapamil. Research methods included a resting ECG, 24-hour ECG monitoring, echocardiography according to the standard protocol. Results. The treatment was initially started in primarily in more severe patients with severe clinical picture. Verapamil intake reduced complains on palpitations beta-blockers reduced clinical signs of angina. Beta-blockers have objectively reduced the number of ventricular extrasystoles. Significant differences were obtained in average grades of ventricular extrasystoles (2.40±0.54 in patients receiving beta-blockers, 1.05±0.22 in patients not receiving beta-blockers, p