Antitumor agents. 49. Tricin,kaempferol-3-0-β-D-glucopyranoside and (+)-nortrachelogenin, antileukemic principles from Wikstroemia indica

: Bioassay-directed isolation of the antitumor extract of Wikstroemia indica (Thymelaeaceae) has led to the characterization of tricin, kaempferol-3-O-beta-D-glucopyranoside, and (+)-nortrachelogenin as the major antileukemic constituents. In addition, daphnoretin was identified as the potent antitumor principle in vivo against the Ehrlich ascites carcinoma growth in mice.