PDGFR- EXPRESSION IN SMALL CELL LUNG CANCER PATIENTS

Background: Platelet derived growth factor (PDGF) and PDGFR- are expressed and have been found to have prognostic value in several human cancers. Data in non-small-cell cancer cell lines have suggested that PDGFR is a therapeutic target for drug development. In the current study PDGFR- expression and prognostic value in small cell lung cancer (SCLC) was investigated. Methods and Materials: Paraffin-embedded tissue blocks from 53 patients with limited and extensive stage SCLC were obtained for immunohistochemical staining. Tumors from each patient were sampled 3 times and stained with PDGFR- specific antibody. Patients were divided into low and high staining groups based on intensity. Results: There was high intensity PDGFR- staining in 20 patients with SCLC. Another 29 expressed low intensity PDGFR- staining, with only 4 patients showing no PDGFR- staining. There was no statistically significant difference in 5 year overall survival between patients with low levels of PDGFR- staining vs. those with high level staining SCLC tumors (p 0.538). Conclusions: The present study found that the majority of SCLC patients express, at least, a low level of PDGF-. However, the level of PDGFR- expression was not a statistically significant predictor of 5 year overall survival in SCLC. © 2007 Elsevier Inc. Platelet derived endothelial growth factor, Lung cancer, Tissue array, STI571, Biomarker, Prognosis.