Synthetic Study of 4-Substituted Piperidine Ring in Elarofiban, RWJ-50042, Tirofiban and Paroxetine

A new strategy for synthesizing a 4-substituted piperidine ring uses the formal [3+3] cycloaddition reaction as the key protocol. This method provides a convenient formal synthesis of elarofiban, RWJ-50042, tirofiban and paroxetine.