Long-term course of lung clearance index among patients with cystic fibrosis
2020
Aim: To investigate the role of age, different types of bronchial infection and pulmonary exacerbations upon lung function deterioration. Methods: 76 children and adults with CF (mean (range) age (years): 10.58 (1.75 to 23.75)) performed 1272 serial Multiple Breath Washout (MBW) measurements and 1047 spirometries over a 7-year period. 289 pulmonary Exacerbations (PEx) were recorded. Bacteria isolated from cough swabs/ sputum cultures were recorded. Patients were divided into 5 age-groups: 20 years. Results: Most lung function parameters showed significant progression with age (FRC, LCI, Scond, M1/M0, M2/M0, FEV1% predicted, FEF50% predicted). LCI deteriorated significantly among the older age groups: ΔLCI ((95% CI))= 0.38 (-0.24 to 1.01), p=0.228, 5-10 years; 1.14 (0.40 to 1.87), p=0.002, 11 – 15 years; 3.02 (2.11 to 3.94), p Conclusion: The LCI demonstrates progression of lung disease and corresponds to changes in bacterial infections and pulmonary exacerbations among patients with CF. LCI may be a useful marker to track disease deterioration and may have a role in the routine clinical care of patients with CF.
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