Gene Mapping of androsterone UDP-glucuronosyltransferase and its deficiency in rat strains

We have regionally assigned the androsterone UDP- glucuronosyltransferase(UGT2B2) gene to rat chromosome 14 at the band p21.2-p22 by fluorescence in situ hybridization. LA Wistar rats have a deficiency of UGT2B2 due to large deletion of the gene. Fischer rats and Nagase analbuminemia rats also show very low UGT2B2 activity similar to LA Wistar rats. It was clarified that the enzyme protein was absent in these strains, however, the molecular mechanism of the defect of UGT2B2 are to be elucidated.