A new flavonol from the stem-bark of Premna fulva

A new flavonol, 4'-hydroxy-8,3'- dimethoxy-6-acroleinylflavan-3,4-diol (1) has been isolated from the ethyl acetate extract of stem-bark of Premna fulva Craib, together with six known compounds, vanillic acid(2), syringaresinol(3), naringenin(4), p-hydroxybenzoic acid (5), apigenin (6) and vitexin (7). The structure of 1 was elucidated on the basis of chemical evidence and intensive spectroscopic analysis including HR-ESI-MS, 1D and 2D-NMR. Compounds 1,3,5,6 and 7 were firstly isolated from this plant. To our regret that compound 1 exhibited no activities towards human cancer cell lines HL-60, BGC-823 and Bel-7402 on the bioassay experiments.