Method of manufacturing the oral mucosa patch buprenorphine formulation

The present invention aims to provide a manufacturing method of the oral mucosa membrane patch buprenorphine formulation. Method of manufacturing an oral mucosa membrane patch buprenorphine formulation according to the present invention, preparing a quick-release layer granules comprising buprenorphine hydrochloride crystal 90% cumulative diameter is 200μm or less; buprenorphine hydrochloride 90% cumulative diameter is 250μm or less preparing a sustained-release layer granules comprising crystalline; and tabletted using the immediate-release layer granules and the sustained-release layer granules for the step of a two-layer tablet; and characterized in that it comprises to.