Kolaviron Stimulates Glucose Uptake with Concomitant Modulation of Metabolic Activities Implicated in Neurodegeneration in Isolated Rat Brain, without Pertubation of Tissue Ultrastructural Morphology.

Abstract Reduced glucose uptake usually occurs in type 2 diabetes due to down-regulation of brain glucose transporters. The potential of kolaviron, a biflavonoid from Garcinia kola to stimulate glucose uptake and suppress glucose-induced oxidative toxicity were investigated in rat brain. Its molecular interactions with the target proteins were investigated in silico. Kolaviron was incubated with excised rat brains in the presence of glucose for 2 h, with metformin serving as a positive control. Kolaviron caused a significant (p