Classification of Primary Cutaneous Large Cell Lymphomas

Primary cutaneous large cell lymphomas represent a heterogeneous group of malignant lymphomas of T- and B-cell origin. Recent studies have been successful in delineating some well-defined clinicopathologic entities within this group. Primary cutaneous follicular (germinal) center cell lymphomas are the most common type of CBCL. These lymphomas generally present with localized skin lesions on the trunk or scalp. They have an indolent clinical course, are highly sensitive to radiotherapy, and have a favorable prognosis. Within the group of primarily cutaneous T-LCL, distinction primarily should be made between CD30-positive (>75% or large clusters of tumors cells) and CD30-negative (no or few scattered positive cells) T-LCL