Effect of Percutaneous Laser Disc Decompression on β-Endorphine and P-Substance in Patients with Protrusion of Lambar Disc Herniation

Objective:To observe the effect of percutaneous laser disc decompression (PLDD) for the patients with protrusion of lumbar intervertebral disc on β-endorphine and P-substance. Method:Seventy-eight patients with lumbar intervertebral disc herniation were randomly divided into two groups. The patients in control group (40 patients) were treated with lumbar spine traction and physical therapy,and those in experimental group (38 patients) were treated with PLDD. β-endorphine and P-substance in the peripheral blood plasma were determined respectively before the procedure and on the first day,the first week,the fourth week after the procedure. Meanwhile the VAS was applied to assess the pain of the patients. Results:On the first day and the first week after the treatment,P-substance in the peripheral blood plasma was reduced,β-endorphine was increased and pain was relived in all the patients. There was significant difference between two groups (P0.001). On the fourth week,the effect obtained in the experimental group was more satisfactory than in the control group (P0.01). Conclusion:PLDD can reduce P-substance and increase β-endorphine in the patients with lumbar intervertebral disc herniation,thus relieving pain. P-substance and β-endorphine can be the objective indexes to evaluate clinical curative effectiveness of relieving pain.