Molecular mechanisms of antithrombin-heparin regulation of blood clotting proteinases. a paradigm for understanding proteinase regulation by serpin family protein proteinase inhibitors

Steven T. Olson,Benjamin Richard,Gonzalo Izaguirre,Sophia Schedin Weiss,Peter G. W. Gettins

Molecular mechanisms of antithrombin-heparin regulation of blood clotting proteinases. a paradigm for understanding proteinase regulation by serpin family protein proteinase inhibitors

2010

Steven T. Olson
Benjamin Richard
Gonzalo Izaguirre
Sophia Schedin Weiss
Peter G. W. Gettins

Serpin family protein proteinase inhibitors regulate the activity of serine and cysteine proteinases by a novel conformational trapping mechanism that may itself be regulated by cofactors to provid ...

Keywords:

Molecular mechanics
Proteinase 3
Heparan sulfate
Serine
Antithrombins
Allosteric regulation
Serpin
Antithrombin
Molecular biology
Biology
Biochemistry
Heparin
Cofactor

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