The Effect of Gelatin Cross-Linking on the Bioequivalence of Hard and Soft Gelatin Acetaminophen Capsules

Marvin C. Meyer,Arthur B. Straughn,Ramakant M. Mhatre,Ajaz S. Hussain,Vinod P. Shah,Carey B. Bottom,Ewart Thomas Cole,Larry L. Lesko,Henry Mallinowski,Roger L. Williams

The Effect of Gelatin Cross-Linking on the Bioequivalence of Hard and Soft Gelatin Acetaminophen Capsules

2000

Marvin C. Meyer
Arthur B. Straughn
Ramakant M. Mhatre
Ajaz S. Hussain
Vinod P. Shah
Carey B. Bottom
Ewart Thomas Cole
Larry L. Lesko
Henry Mallinowski
Roger L. Williams

Purpose. To determine if changes in the in vitrodissolution of hard and soft gelatin acetaminophen capsules, which resultfrom gelatin crosslinking, are predictive of changes in the bioavailabilityof the capsules in humans.

Keywords:

Acetaminophen
Bioequivalence
Gelatin
Chemistry
Hard Capsule
Dosage form
Chromatography
pharmacology toxicology
pharmaceutical technology

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