Monte Carlo simulation of DNA strand breaks induced by monoenergetic electrons using higher-order structure models of DNA

A new theorerical model for estimating yield of initial DNA strand break induced by several monoenergetic electrons is presented. It is based on the Monte Carlo track structure simulation and on new DNA structure models (one turn of double-strand DNA, nucleosome, solenoid), and links physical and chemical stages of radiation action. Direct and indirect effects are strictly distinguished. Some results of calculations indicated: (1) the number of single strand breaks per nucleus (6 μm in diameter) per Gy in pure water was about 10 rimes that in a cell environment (OH radical life rime is assumed to be 87 ns)