Antibody blockade of semaphorin 4D to sensitize pancreatic cancer to immune checkpoint blockade.

Luis I. Ruffolo,Nicholas A. Ullman,Benjamin Dale,Katherine M. Jackson,Paul Burchard,Mary Georger,Rachel Jewell,Brian A. Belt,Eva Galka,Luke O. Schoeniger,Crystal Mallow,Elizabeth E. Evans,Terrence L. Fisher,Maurice Zauderer,David C. Linehan

Antibody blockade of semaphorin 4D to sensitize pancreatic cancer to immune checkpoint blockade.

2020

Luis I. Ruffolo
Nicholas A. Ullman
Benjamin Dale
Katherine M. Jackson
Paul Burchard
Mary Georger
Rachel Jewell
Brian A. Belt
Eva Galka
Luke O. Schoeniger
Crystal Mallow
Elizabeth E. Evans
Terrence L. Fisher
Maurice Zauderer
David C. Linehan

26Background: Pancreatic ductal adenocarcinoma (PDAC) carries a dismal prognosis, and will soon become the second leading cause of cancer mortality. Unfortunately, T-cell directed immunotherapies h...

Keywords:

Antibody
Immune checkpoint
Pancreatic cancer
pancreatic ductal adenocarcinoma
Cancer
Blockade
Cancer research
Medicine
Semaphorin
Pathology
cancer mortality
semaphorin 4d

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