Histological, Immunohistochemical, Ultrastructural and Biochemical Study of Human Gastric Composite Tumor: Expression of the Serotonin-2B Receptor by the Neuroendocrine Component
2001
We report a case of a human gastric composite tumor occurring seven years after a partial gastrectomy for a low grade B cell MALT lymphoma. Histological examination of the tumor revealed two intimately intermingled components:
1.
A moderately to poorly differentiated tubulo-acinar adenocarcinoma with signetring cells; and
2.
Isolated or clustered small neuroendocrine cells without atypia expressing chromogranin A, somatostatin and/or glucagon, serotonin (5-HT) and, the 5-HT2B receptors. In addition to immunohistochemical detection, the presence of 5-HT2B receptors was shown pharmacologically through [125l]-DOI binding.
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