Autologous Retinal Transplantation for Primary and Refractory Macular Holes, and Macular Hole Retinal Detachments: The Global Consortium.

Abstract Purpose To report the anatomical and functional outcomes of autologous retinal transplantation (ART). Design Multicenter, retrospective, interventional, consecutive case series. Participants 130 eyes of 130 patients undergoing ART for the repair of primary and refractory macular holes, as well as combined macular hole-rhegmatogenous retinal detachments (MH-RRD), between January 2017 and December 2019. Methods All patients underwent pars plana vitrectomy and ART, with surgeon modification of intraoperative variables. A large array of preoperative, intraoperative, and post-operative data was collected. Two masked reviewers graded optical coherence tomography (OCT) images. Multivariate statistical analysis and subgroup analysis were performed. Main outcome measures Macular hole closure rate, best corrected visual acuity (VA), external limiting membrane, ellipsoid zone (EZ) integrity, and alignment of neurosensory layers (ANL) on OCT. Results 130 ART surgeries were performed by 33 vitreoretinal surgeons worldwide. Patient demographics were: mean age 63±6.3 years, 58% females, 41% Caucasian, 23% African, 19% Asian, and 17% Latino. Preoperative logMAR VA was 1.37±0.12 (∼20/500), which improved significantly to 1.05±0.09 (about 20/225; p Conclusion In this global experience, patients undergoing ART for large, primary and refractory macular holes, and MH-RRDs, achieved good anatomical and functional outcomes, with low complication rates despite complex surgical pathology.