Atherosclerosis progression in antiphospholipid syndrome is comparable to diabetes mellitus: a 3-year prospective study.

Background Antiphospholipid syndrome (APS) is an autoimmune thrombophilia leading to life-threatening cardiovascular events. Cross-sectional data support that APS is associated with accelerated atherosclerosis, but this has not been confirmed in prospective studies. We aimed to compare the rate of atherosclerosis progression over a 3-year period between patients with APS, diabetes mellitus (DM) and healthy controls (HC). Methods Eighty-six patients with APS (43 with primary [PAPS], 43 with systemic lupus erythematosus-related APS [SLE/APS]) and an equal number of age- and sex-matched patients with DM and HC, who underwent a baseline ultrasound of the carotid and femoral arteries, were invited for a 3-year follow-up evaluation for atherosclerotic plaque progression. Multivariate analysis was performed for the assessment of determinants of plaque progression after adjustment for disease-related and traditional cardiovascular risk factors. Results Seventy-four APS patients (74.3% female, 38 with PAPS), 58 DM patients and 73 HC were included. APS patients exhibited a 3.3-fold higher risk of new atherosclerotic plaque formation compared with HC (p= 0.031), similar to that in DM (odds ratio [OR]=3.45, p= 0.028). In APS patients, plaque development risk was higher in SLE/APS vs PAPS (OR = 7.75, p= 0.038) and was independently associated with the presence of traditional cardiovascular risk factors, as expressed by the Systematic Coronary Risk Evaluation (SCORE) risk (OR = 2.31, p= 0.008). Conclusion APS is characterized by accelerated rates of subclinical atherosclerosis to a degree comparable to DM, which is more pronounced in SLE/APS patients. Traditional cardiovascular risk factors are major determinants of this risk, warranting aggressive management as in other high cardiovascular-risk disorders.