GW27-e0632 NR reduced myocardial ischemia-reperfusion injury by improving mitochondrial biogenesis and reducing excessive autophagy via Sirt3-PGC-1α/P53 pathway

The purpose of this study is to investigate whether nicotinamide riboside(NR), a newly discovered NAD+ precursor occurring in milk, could reduce myocardial ischemia-reperfusion injury by regulating autophagy and its mechanisms. We utilized an in vivo mouse model of myocardial I/R injury and an in