Study about interleukin-1 receptor antagonist gene polymorphism in patients with lung cancer

Objective To investigate the relationship between interleukin-1 receptor antagonist gene (IL-1RN) polymorphism and the susceptibility of lung cancer by studying IL-1RN gene polymorphism of lung cancer patients and healthy people. Methods IL-1RN gene polymorphism in 148 patients with lung cancer and 150 healthy individuals was analyzed by polymerase chain reaction. Results The class Ⅱ allele (IL- 1RN * 2) significantly reduced the risk of lung cancer (OR=0.46,95% CI:0.23-0.93). IL-1RN*2was associated with significantly reduced risk by comparing with transfer patients and Ⅱ -Ⅳ stage patients (OR =0.37,95%CI :0.14-0.98;OR=0.38,95%CI:0.16-0.87).Conclusions IL-1RN*2 canreduce the risk of lung cancer, may be related to metastasis and progression of lung cancer. Key words: Interleukin-1;  Receptor; Gene polymorphism;  Lung cancer