An extraction strategy to determine a permissible region for fluorescence molecular tomography

Fluorescence molecular tomography (FMT) is an optical molecular tomography technology with great promise, and it has broad application prospects for its high sensitivity. However, it is still a challenge in reconstruction because of its severe ill-posedness. In this study, a new extraction strategy to determine a permissible region of target is proposed for FMT, which can provide a definite central position and size of the permissible region. Numerical simulation experiments and an in vivo experiment have been carried out to verify the performances of the strategy. The experimental results demonstrated that the strategy can provide a permissible region of target with a definite position and size, which further allowed a steady and accurate reconstruction for FMT.