Perilla Extract Improves Lower Urinary Tract Symptoms and Sleep in Japanese Adults ―A Randomized Double—blind Placebo—controlled Crossover Study―

Objectives　Perilla, a traditional functional herb used in Asia for its antioxidant, anti-inflammatory, and anti-allergic effects, has been shown to improve frequent urination and related symptoms in an animal model. Here, our objective was to investigate the influence of Perilla extract on lower urinary tract symptoms（LUTS）and sleep in Japanese adults. Methods　Twenty eligible Japanese men and women in this randomized double-blind placebo-controlled crossover study were given Perilla extract（PE）or placebo tablets for 4 weeks. LUTS and quality of sleep were investigated using the overactive bladder symptom score, micturition diary, and activity-based sleep monitor before and after the intake of the tablets. Results The total score and subscore of nocturia frequency in overactive bladder symptom score decreased significantly after the intake of PE tablets for 2 weeks compared with before tablet intake. A significant improvement in sleep efficiency was observed in the PE group compared with placebo group after ingestion for 4 weeks. Particularly, women in the PE group showed a significant improvement in the mean change in voided volume per micturition and number of daytime micturition compared with women in the placebo group. Conclusions　PE may be a useful option for alleviating LUTS and nocturnal awakening associated with bladder storage dysfunction.（UMIN-CTR/UMIN000033923）