Abstract 20433: Role of Cardiac Implantable Device Therapy in Patients With ATTR Wild Type Amyloidosis : A Retrospective Analysis of Mortality Outcomes

Introduction: The role of cardiac implantable electronic device(CIED) therapy in patients with ATTR (senile) amyloid is not very well defined. Methods: We performed a retrospective analysis of a prospectively collected registry of patients with biopsy proven ATTR amyloid, followed up at Mayo Clinic, Rochester, Minnesota between Jan 1,1985 to Sep 30, 2015. The follow-up of these patients after diagnosis was done via personal communication, either written or verbal, and entered into the database. During analysis these patients were subdivided on the basis of the presence or absence of a CIED and all-cause mortality outcomes were analyzed using X2 test of significance and RR determined. In addition, CIEDs were subdivided into pacemakers, defibrillators(ICDs) and cardiac resynchronization devices(CRT-P/D) and the mortality among the patients with each device subtype was estimated and compared to overall mortality. Absolute risk reduction(ARR) and relative risk reduction(RRR) ratios were calculated for each gr...