Abstract 14385: Genome Sequencing and Re-Engineered Heart Cell-Disease Modeling Identifies a Novel Deep Intronic Variant in a Multi-Generational Long QT Syndrome Pedigree

Introduction: Most of long QT syndrome (LQTS) is explained by pathogenic variants in KCNQ1, KCNH2, or SCN5A. However, ~10-20% of LQTS index cases remain genetically elusive following commercial gen...