Pyoderma gangrenosum in a patient on ixekizumab.

Pyoderma gangrenosum (PG) is a rare, inflammatory neutrophilic dermatosis that can have extracutaneous manifestations.1 Here, we present a patient with psoriasis on ixekizumab who first presented with a vaginal cuff abscess, with subsequent development of skin lesions on the hands, feet, and face. She was diagnosed with PG, initially treated with cyclosporine, and transitioned to adalimumab, with resolution of the cutaneous lesions and associated pain.