P13.13 Trans-endothelial migration of non-small cell lung cancer cells: Role of CD15 and CD15s in brain metastasis

Introduction: Metastatic non-small cell lung cancer represents the most common cause of brain metastasis in adults. Interaction between circulating cancer cells and brain endothelial cells play a key role in brain metastasis, but their underlining molecular mechanisms are still not fully understood. The CD15 and CD15s epitopes function as cell adhesion molecules and are known to be correlated with metastasis in non-CNS cancers. This study aims to investigate the role of CD15 and CD15s in cancer cell adhesion and trans-endothelial migration during metastasis to the brain by perturbing the expression of the fucosyltransferases responsible for the synthesis of these epitopes.