Procedure for Synthesis of mandipropamid and derivatives thereof

A process for the preparation of a compound of formula (I) ** ** Formula where: R is an alkynyl group; R1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, phenyl and phenylalkyl, it being possible, in turn, to record all groups carry one or more atoms of identical or different halogen; alkoxy; alkenyloxy; alkynyloxy; alkoxyalkyl; haloalkoxy; alkylthio; haloalkylthio; alkylsulfonyl; formyl; alkanoyl; hydroxy; halogen; cyano; nitro; Not me; alkylamino; dialkylamino; carboxyl; alkoxycarbonyl; alkenyloxycarbonyl; or alkynyloxycarbonyl; n is an integer from 0 to 3, said process comprising: (i) reacting a compound of formula (III) ** ** Formula wherein R, R1 and n are as indicated above for the compound of formula ( I); m and m 'they are independently 0 or 1, and when any of m and m' is 0, the other is 1, and A is an alkanediyl group, alkenediyl or alkynediyl containing at least two carbon atoms (and suitably having up to eight carbon atoms ), optionally substituted with one or more groups independently selected from halogen, hydroxy, alkoxy, C1-4 dialkyl-amino or cyano; omym 'are both 1, A is an alkanetriyl group alquenotriilo or alquinotriilo containing at least three carbon atoms (and suitably having up to eight carbon atoms), optionally substituted with one or more groups independently selected from halogen, hydroxy alkoxy, C1-4 dialkyl amino or cyano; and wherein if the group A contains three or more carbon atoms, one or more of the carbon atoms may each be optionally replaced by an oxygen atom, with the proviso that at least one carbon atom between any two oxygen atoms in the molecule, with a compound of formula (IV) ** ** formula to give a compound of formula (II) ** ** formula wherein R, R1 and n are as stated above for compound of formula (I), and reacting the compound of formula (II) where ** ** formula is a leaving group, to give the compound of formula (I).