Profil epidemio-clinique actuel des co-infections VHB/VIH et VHC/VIH au Centre Hospitalier Universitaire du Point- G, Bamako Mali

2020 
Objectif: Determiner la place du portage des virus des hepatites B et C chez les PVVIH admis en hospitalisation. Methodologie: L’etude etait retrospective et descriptive sur 10 ans a partir de la base de donnees, dans les services de references des hepatites virales B et C. Elle a concerne les patients porteurs du VIH et d’antigene HBs et/ou Ac anti-VHC. Resultats: Sur 3024 patients hospitalises, 123 cas de coinfections (4,07%) de VIH + VHB (n =115) et VIH+VHC (n =8) ont ete recenses. L’âge moyen des patients ayant une coinfection VIH/VHB etait de 40,2 ans ± 15,6 vs 43,05 ± 2,07 pour ceux ayant une co-infection VIH/VHC et le sex-ratio (H/F) de 0,33 pour les patients VIH/VHB versus 1,5 pour les patients VIH/VHC. Les facteurs de risque identifies etaient les partenariats sexuels multiples (50,4%), la transfusion sanguine (5,69%), la sodomie (2,4%) et l’injection intraveineuse de drogues (2,4%). Les patients VIH-VHB etaient sous traitement ARV dans 67,8% des cas (35,6% par TDF/3TC/EFV) compares aux patients VIH-VHC (traites par AZT/3TC/EFV). Aucune triple association VIH/VHB/VHC n’etait diagnostiquee. Conclusion: la co-infection VIH et hepatites virale B et C reste non negligeable en hospitalisation. Le respect des normes de traitement ARV nationales reduiraitle poids de la morbi-mortalite associee a la comorbidite avec le VHB. L’espoir des prochaines subventions du traitement du VHC serait un gage de reduction de sa mortalite. Mots cles: Comorbidite, Infection a VIH, Hepatite a virus B, Hepatite a virus C English Title: Epidemiological and clinical current profile of HBV/HIV and HCV/HIV to the University Hospital Center Area of Point-g, Bamako, Mali English Abstract Objective: To determine the place of hepatitis B and C viruses infection among PLVIH admitted to hospital. . Method: Study was a retrospective and descriptive study over 10 years, from the database in the reference services of viral hepatitis B and C. Results: Of 3024 hospitalized patients, 123 co-infections (4.07%) of HIV + HBV (n = 115, 93.5%) and HIV + HCV (n = 8, 6.5%) were detected. Their mean age was 40.2 years ± 15.6 (HIV / HBV) vs 43.05 ± 2.07 for the HIV / HCV couple with a sex ratio (M / F) equal 0.33 for HIV / HBV couple and 1.5 for HIV / HCV couple. The risk factors identified were multiple sexual partnerships (50.4%), blood transfusion (5.69%), sodomy (2.4%) and intravenous drug injection (2.4%). The carriers of the HIV-HBV couple were on Antiretroviral treatment (67, 8%) particularly treat by TDF / 3TC / EFV in 36,5% compared to the HIV-HCV couple (treated with AZT / 3TC / EFV). No triple case of HIV / HBV / HCV association was diagnosed. Conclusion: HIV coinfection and viral hepatitis B and C remain significant in admission. Compliance with national ARV treatment standards would reduce the burden of morbidity and mortality associated to comorbidities of HBV. Hope for future HCV treatment grants would be a pledge to reduce mortality associated to this virus. Keywords: Comorbidity, HIV infection, Hepatite B, Hepatite C
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