Molecular Events in Growth Hormone–Receptor Interaction and Signaling
2011
The sections in this article are:
1
The Growth Hormone Receptor
1.1
Cloning of the Growth Hormone Receptor
1.2
The Cytokine/Hematopoietin Receptor Superfamily
1.3
Growth Hormone Binding and Receptor Dimerization
2
Growth Hormone–Dependent Intracellular Signaling
2.1
Activation of the Tyrosine Kinase Janus Kinase 2
2.2
Tyrosyl Phosphorylation of the Growth Hormone Receptor and Janus Kinase 2
2.3
Activation of the Ras–Mitogen-Activated Protein Kinase Signaling Pathway
2.4
Utilization of Insulin Receptor Substrates 7 and 2 and Phosphatidylinositol-3′-Kinase
2.5
Regulation of Protein Kinase C
2.6
Regulation of Intracellular Calcium
2.7
Activation of Stat Proteins
3
Growth Hormone-Dependent Signaling to the Nucleus
3.1
Multiple Pathways Mediate Growth Hormone–Regulated Gene Expression
3.2
Sexually Dimorphic Growth Hormone Secretion Patterns Regulate Gene Transcription
4
Conclusions
Keywords:
- Endocrinology
- Thyrotropin-releasing hormone receptor
- Tropomyosin receptor kinase C
- JAK-STAT signaling pathway
- Internal medicine
- Growth-hormone-releasing hormone receptor
- Insulin-like growth factor 1 receptor
- Janus kinase 2
- Growth factor receptor
- Cell biology
- Biology
- Molecular biology
- Growth hormone receptor
- growth hormone secretion
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