CLINICAL EFFECTIVENESS OF BRONCHO-VAXOM (BV) IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Summary: Sixty-two adult patlents of both sexes with chronic obstructive pulmonary d/sease (COPD) partic/pated In a double-blind, placebo-controlled trial to determine the effecfs of treatment wlth BronchoVaxom (BV), an immunomodulating agent. adminlstered orally in capsule form Clincal manifestations, frequency, duration and severlty of acute exacerbations, consumption of convenhonal medicatlons and serum immunoglobulin levels were observed over a period of 6 months during the autumnlwmter of 1990- 7997 Treatment with BV produced a stat/stca/ly slgnificant decrease. espeoally alter the thud month, In the mean score of the chical slgns. as well as in the cumulatlve index and in the number, severity and duration of acute exacerbatlons. In addition, a significant reduction in the use of conventional therapy was notlced.