Analyses of 99Tcm-DTPA dynamic kidney imaging on 346 patients of upper urinary tract calculi

Objective To explore the clinical value of 99Tcm-DTPA renal dynamic imaging in evaluating renal function of the patients with upper urinary tract calculi. Methods The results of 99Tcm-DTPA renal dynamic imaging, glomerular filtration rate(GFR), intravenous pyelography(IVP), blood urea nitrogen (BUN) and serum creatinine(SCr) in 346 patients with upper urinary tract calculi diseases were analyzed retrospectively. These 346 patients were divided into four groups according to their total GFR value. Results ① The renal dynamic imaging in 346 patients could accurately reflect the function of the two kidneys. GFR was negatively related to the serum BUN and SCr levels (r=-0.458, P=0.000 and r=-0.542, P=0.000). ② The BUN and SCr levels showed significant difference among the four groups(F=49.23,P=0.000 and F=80.66,P=0.000). There were no significant difference of the BUN and SCr levels found between group 1 and group 2 (P=0. 119, P=0.088, respectively), while significant difference of the BUN and SCr levels found among the other groups P＜0.05 for all situations). ③ Forty-three kidneys of the 346 patients were not visualized by IVP, while 18 of them (41.9%) had shown residual function (GFR ≥10ml/min) with 99Tcm-DTPA renal dynamic imaging, the mean GFR was( 21.89±12.81 )ml/min. Conclusion 99Tcm-DTPA renal dynamic imaging is valuable to early evaluate the renal function, especially for the sick renal function in IVP detection failed patients. Key words: Urinary calculi;  Radionuclide imaging;  Technetium 99Tcm pentetate;  Glomerular filtration rate;  Urography