Assessment of Iron Concentration by Direct Saturation Imaging (DSI) in a Two- Pool Model of Brain Tissue

Deposition of nonheme iron in the brain is linked with the process of normal ageing and with a variety of neurological disorders including Multiple Sclerosis, Alzheimer’s and Parkinson’s disease. Although different MRI approaches for the in vivo assessment of iron concentration exist, they altogether lack validation by histopathological correlation which renders their evaluation and comparison challenging.