4 g/L.day: Monoclonal Antibody Volumetric Productivity in the iCELLis TM Disposable Fixed-Bed Bioreactor

Artelis/ATMI LifeSciences has developed a novel scalable fixed-bed bioreactor – iCELLis™ based on a proprietary agitation system, a waterfall oxygenation of medium and a packed-bed made up of macroporous carriers. Process intensification, which reduces bioreactor volumes and simplifies operations, provides a key competitive advantage in the fast-growing monoclonal antibody market Here we present a case study on the production of a model monoclonal antibody using high performance rCHO Selexis’ Genetic Elements™ cells in perfusion mode in such fixed-bed iCELLis reactor.