Dual gene activation and knockout screen reveals directional dependencies in genetic networks

Michael Boettcher,Ruilin Tian,James A Blau,Evan Markegard,Ryan T Wagner,David Wu,Xiulei Mo,Anne Biton,Noah Zaitlen,Haian Fu,Frank McCormick,Martin Kampmann,Michael T. McManus

Dual gene activation and knockout screen reveals directional dependencies in genetic networks

2018

Michael Boettcher
Ruilin Tian
James A Blau
Evan Markegard
Ryan T Wagner
David Wu
Xiulei Mo
Anne Biton
Noah Zaitlen
Haian Fu
Frank McCormick
Martin Kampmann
Michael T. McManus

Combining gene activation and knockout of different genes in the same cell using two different Cas9 enzymes enables the reconstruction of directional dependency.

Keywords:

Molecular biology
Regulation of gene expression
Cell
Biology
Enzyme
Gene
Cas9
Computational biology

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