Brain metastasis due to triple-negative breast cancer in the Peruvian population.

e14013Background: Breast cancer is an important cause of cancer-related death in women worldwide and represents the second most frequent cause of brain metastases after lung cancer. The aim of this study was to determine the characteristics and outcomes of Brain Metastasis (BM) due to Triple Negative Breast Cancer (TNBC). Methods: We retrospectively reviewed a database of 2007 pts diagnosed with TNBC at the “Instituto Nacional de Enfermedades Neoplasicas” (period 2000-2014) to select pts who developed BM. Survival rates were assessed by Kaplan-Meier method, and prognostic factors were identified with Cox regression analysis. Results: Of our study population, 9.62%(N = 193) of pts developed BM. The median age was 46 years (range:21-92); 103(54.8%) were premenopausal, and 172 (89.1%) had a family history of breast and/or ovary cancer. BM occurred in 4(2.1%) pts with clinical stage (CS) I, 24(12.5%) with CS II, 141(73.4%) with CS III and 23(12%) with CS IV. Neoadjuvant chemotherapy was administered in 121 (6...