The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation.

I. Introduction II. Regulation of the Cell Cycle G1 Phase A. The cyclins B. The Cdk-inhibitory proteins C. Regulation of transcription by cell cycle-control proteins III. Endocrine Regulation of Cyclin and Cdk-Regulatory Proteins A. Single-transmembrane segment receptors B. Seven-transmembrane receptors C. Steroid hormones D. Intracellular second messengers IV. Cyclins and CKIs in Endocrine Tumors A. Parathyroid adenomas B. Thyroid cancer C. Pituitary tumors D. Adrenal tumors E. Ovarian and testicular cancer F. Mechanisms of oncogenic transformation by cyclin D1 G. CKIs in treatment of endocrine disease V. Transcription Factors Regulating the Cell Cycle VI. Conclusion