원저 : 자외선에 의한 일광화상세포 형성에 미치는 세포분열 변화의 영향

The influence of ultraviolet light(UVL) upon sunburn cell(SBC) formation according to the change of mitosis was studied in mouse skin. Decrease of mitosis which suppress cell proliferation was done by methotrexate (MTX) intradermal injection. Increase of mitosis which stimulate cell proliferation was performecl by tape stripping(TS). A total of 75 ICR female albino mice was used in this study. UV light source was UVB using high pressure mercury arc. The arnount exposed was 100m J/cm. 1. The number of SBC in 1cm epidermis after UVI exposure was 42.4+20.9. The number of SBC was decreased by MTX injection(18.4+9.2), and increased by TS(78.5:+ 12.8). 2. Labelling index(LI, %) in normal mouse skin was 8.9+1.8. LI was decreased by MTX injection(4.4+1.7), and markedly increased by TS (24.2 l- 4.7). These results suggest that the change of mitosis which correlated with cell proliferation influence the SBC formation by UV exposure. (Kor J Dermatol 28(3): 269 277, 1990)