Computational Study of Parameters of Needle Electrodes for Electrochemotherapy

Electroporation is a phenomenon that increases cells permeability due to applications of electric fields. Electrochemotherapy uses electroporation to facilitate drugs insertion into tumor cells. Guarantee that all tumor tissue will be electroporated is vital to treatment success. Needle electrodes can present complex electric field distribution. This paper aims to study electric field changes due to variations in electrodes and application protocols parameters. Besides, we suggest a superposition approach to improve electroporation treatment.