Artemisinin derivatives and application thereof

The invention belongs to the technical field of medicaments, and relates to artemisinin derivatives shown in a general formula I, in particular to a series of artemisinin aromatic ethers, artemisinin aliphatic ethers, artesunate derivatives and optical active bodies thereof, wherein substitutional groups, namely X, Y, R1, R2, R3, R4, R5, R6, R7, R8 and R9 have definitions given in an instruction book. The derivatives and compositions thereof can be made into clinically acceptable formulations such as tablets, capsules, injections, ointment and the like, and are used for inducing the apoptosis of tumor cells and treating and/or preventing cancer.