Campylobacter vaccine development:a key to controlling enteric diseases

Worldwide, Campylobacter jejuni is a major cause of diarrhoea and dysentery, with approximately 400 million cases occurring annually. Control of the disease through public health and antibiotic measures is insufficient, and vaccination offers the most promising solution. Infection produces immunity from disease, suggesting that vaccination may produce similar protection. Epidemiological data suggest that there are conserved antigens among serotypes; immunity against which protects against disease. Therefore a monovalent serotype vaccine seems practical. Several antigens on Campylobacter have been found to be immunogenic and, in some cases, associated with virulence. However, none of these proteins have been produced recombinantly in the proper conformation, nor have they been protective in preclinical models. For this reason, live attenuated or inactivated Campylobacter whole cell (CWC) vaccines may be the best approach. Development of an attenuated strain of Campylobacter has been complicated by the fact...