Human papillomavirus type 18 variants: histopathology and E6/E7 polymorphisms in three countries.

In the present study, we assessed the distribution of intratypic HPV 18 and HPV 16 variants in ADCs and SCCs. Moreover, we did a sequence analysis on the E6 and E7 open reading frames (ORFs). We performed this study in patients from 3 different countries in order to investigate a wide range of ethnicities and variants. In the Indonesian group, a large majority of women are Javanese.5 The Surinamese population consists of several ethnical groups, the most important being the Creoles, Hindustani, Javanese, bush Negro and Amerindians.4 In the Netherlands, the majority of the population is Caucasian. We observed that HPV 18 intratypic variants are differentially distributed in ADCs and SCCs.