Method for antipodal selective synthesis of (R)-lansoprazole
2013
The invention relates to a preparation method for efficient synthesis of (R)-lansoprazole, and according to the method, in the presence of an asymmetric induction catalyst, an oxidant with 1.3 to 1.5 times molar equivalent relative to prochiral compound lansoprazole thioether is used for selective catalytic oxidation to obtain the (R)-lansoprazole. The method has the advantages of being economic, environmentally friendly, high efficiency, high in optical purity and high in chemical purity of products, and is a method suitable for industrialized production.
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