Wnt-1诱导分泌蛋白－1在乳腺浸润性导管癌中的表达及其临床意义

Objective To investigate the expression of Wnt-1 induced secreted protein-1 (WISP-1) between breast cancer and paired normal breast tissues and to explore the significance of WISP-1 in breast cancer tumorigenesis. Methods The mRNA and protein expressions of WISP-1 in human breast cancer were measured by Quantitative Real-Time RT-PCR and immunohistochemical staining and further analyzed the relationship between WISP-1 expression and clinic pathologic characters. Results WISP-1 expression in breast cancer was higher than that in normal breast tissue (P=0.001). The mRNA expression level of WISP-1 was correlated with tumor size, staging, lymph node status, differentiated degree and HER-2 status (P＜0.05). WISP-1 protein expression level was correlated with lymph node status, differentiated degree and HER-2 status (P＜0.05). Conclusion WISP-1 expression in human breast cancer increases significantly and may play a key role in the invasion and metastasis of human breast cancer.